ASOCIACION DEL POLIMORFISMO VAL108/158 MET Y RESPUESTA AL TRATAMIENTO CON LITIO
DOI:
https://doi.org/10.36790/epistemus.v12i24.56Keywords:
Transtorno Bipolar, Gen COMT, LitioAbstract
Se realizó un estudio prospectivo, descriptivo y de asociación de casos y controles con respuesta y no respuesta al tratamiento con litio. Se realizó posteriormente extracción de DNA por medio de buffy coat y, genotipificación del rs4680 mediante el método fluorogénico 5´-exonucleasa y discriminación alélica por el software applyed biosystem 1.3 V. Se utilizó la escala de Alda para valorar la respuesta a litio. El análisis estadístico se realizó por el programa SPSS. El análisis entre los pacientes respondedores y no respondedores a litio no mostró diferencias estadísticamente significativas tanto entre las frecuencias genotípicas (X2 =2.07, p = 0.354) y las alélicas (X2 = 0.39, p = 0.529. No se encontró asociación significativa entre el polimorfismo del rs4680 entre los respondedores y no respondedores a la terapia con litio, por lo que una sugerencia seria ampliar más la muestra de estudio para tener una conclusión final.
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References
P. Timms. “TRASTORNO BIPOLAR (MANÍACO DEPRESIVO)”. Royal Collage of Psychiatrists, 2007.
C.M. Bonnin, A. Martinez-Aran. “Trastorno bipolar, funciones cognitivas y eje hipotalámico-pituitario-tiroideo”. Universidad de Barcelona, 2010.
Guía de Práctica Clínica, “Diagnóstico y Tratamiento del Trastorno Bipolar”, México Secretaría de Salud, 2009.
P. Alexis GEOFFROY, Bruno ETAIN. “Circadian genes and lithium response in bipolar disorders: Associations with PPARGC1A (PGC-1α) and RORA.” . Genes Brain Behav,2016. DOI: https://doi.org/10.1111/gbb.12306
L. Hou, E. Bergen. “Genome-wide association study of 40,000 individuals identifies two novel loci”. Oxford University, 2016.
J. Oedegaard, M. Alda. “The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample”. BMC Psychiatry, 2016. DOI: https://doi.org/10.1186/s12888-016-0732-x
L. Hou, U. Heilbronner. “Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study”, 2016; http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)00143-4/abstract.
S. Hossein Fatemi, J. Reutiman, D. Folsom. “The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder”. Biochemical Society Transactions vol. 37, 2009. DOI: https://doi.org/10.1042/BST0371090
H. Silva. “Mecanismos de acción de los estabilizadores del ánimo’”, Revista chilena de neuro-psiquiatría, 2001. DOI: https://doi.org/10.4067/S0717-92272001000300006
J. García. “Neuroquímica de los trastornos bipolares”. http://www.psiquiatria.com/articulos/trastorno_bipolar/2156/ (accessed http://documents.mx/documents/neuroquimica-de-los-trastornos-bipolarespdf.html).
S. Souza MG, M. Vieira. “COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder”. Bipolar Disorders, 2012.
F. Benedetti, S. Dallaspezia. “Association between ctechol-O-methyltransferase Val (108/158) Met polymorphism and psychotic features of bipolar disorder”. Journal of Affective Disorders, 2010; www.elsevier.com/locate/jad. DOI: https://doi.org/10.1016/j.jad.2010.01.005
H. Lee, Y. Kim. “Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients”. Psychiatry Research, 2008; www.elsevier.com/locate/psychres.
J. Rybakowski. “Factors associated with lithium efficacy in bipolar disorder”. Harv Rev Psychiatry vol 22, 6, 2014. DOI: https://doi.org/10.1097/HRP.0000000000000006
B. Baune, C. Hohoff, K. Berge. “Association of the COMT val158met Variant with Antidepressant Treatment Response in Major Depression”. Neuropsychopharmacology 2008; www.neuropsychopharmacology.org DOI: https://doi.org/10.1038/sj.npp.1301462
K. Janusz. Rybakowski. “Genetic Influences on Response to Mood Stabilizers in Bipolar Disorder”. CNS Drugs, 2013; Springerlink.com. DOI: https://doi.org/10.1007/s40263-013-0040-7
M. Muñiz de la Torre. “TRATAMIENTO FARMACOLÓGICO DEL TRASTORNO BIPOLAR’”, Unidades Docentes de Psiquiatría del Instituto Psiquiátrico José Germain de Leganés y del Hospital Universitario 12 de Octubre (Madrid), 2001.
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